Research Articles
  1. High‑Intensity Functional Training: Molecular Mechanisms and Benefits​. B. Zeev T and Okun E. NeuroMolecular Medicine. 01 January 2021.
  2. Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis. Illouz T, Nicola R, Ben-Shuhan L, Madar R, Biragyn R and Okun E.

  3. Mild physical activity does not improve spatial learning in a virtual environment.
    Okun E, B. Zeev T, Weiss I, Ashri S, Heled Y, Ketko I and Yanovich R. Front. Behav. Neurosci. 17 november 2020.

  4. The effects of High-Intensity Functional Training (HIFT) on spatial learning, visual pattern separation and attention span in adolescents. 
    Okun E, Ben-Zeev T, Hirsh T, Weiss I and Gornstein M. Front. Behav. Neurosci. 21 August 2020.

  5. Food and Age: It Takes Two to Degenerate​. 
    Nicola R and Okun E. Front. Aging Neurosci., 26 June 2020.

  6. A modified Barnes maze for an accurate assessment of spatial learning in mice. 
    Illouz T, Madar R and Okun E. J Neurosci Methods. Jan 2020.

  7. L-Lactate Promotes Adult Hippocampal Neurogenesis. 
    Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Feldman N, Roichman A, Illouz T, Varvak A, Nicola R, Madar R and Okun E. Front. Neurosci., 24 May 2019. 

  8. Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model.
    Illouz T., Madar R., Biragyn A. and Okun E. Brain, Behavior, and Immunity, 2018 Oct 23.

  9. Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair.
    De Lorenzo G, Ferrari S, Cervone F and Okun E. Trends Immunol. 2018 Oct 4.

  10. The Toll Pathway in the Central Nervous System of Flies and Mammals.
    Shmueli A, Shalit T, Okun E and Shohat-Ophir G. Neuromolecular Med. 2018 Oct 1.

  11. Dopamine receptors in the rat entopeduncular nucleus.
    Lavian H, Loewenstern Y, Madar R, Almog M, Bar-Gad I, Okun E and Korngreen A. Brain Struct Funct. 2018 Mar 22.
  12. Deficiency of Toll-like receptors 2, 3 or 4 extendslife expectancy inHuntington’s disease mice. Griffioen K, Mattson MP, Okun E. Heliyon. 2018 Jan 18.
  13. A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42
    Illouz T , Madar R, Griffioen K and Okun E. J Neurosci Methods. 2017 Nov 1.

  14. Dopaminergic modulation of synaptic integration and firing patterns in the rat entopenduncular nucleus. 
    Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A. J Neurosci. 2017 Jun 26.

  15. Sirt6 alters adult hippocampal neurogenesis.
    Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY. PLoS One. 2017 Jun 23.

  16. The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study.
    Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun EYadid G and Popovtzer R. Nanomedicine. 2017 June 16.

  17. Toll-like receptor 3 deficiency decreases epileptogenesis in pilocarpine model of SE-induced epilepsy in mice.
    Gross A, Benninger F ,Madar R, Illouz T, Griffioen K, Steiner I, Offen D and Okun E. Epilepsia. 2017 Feb 6.

  18. Unbiased classification of spatial strategies in the Barnes maze. 
    Illouz T , Madar R, Clague C , Griffioen K, Louzoun Y and Okun E. Bioinformatics. 2016 July 4.

  19. Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm.
    Illouz T, Madar R, Louzon Y, Griffioen KJ, Okun E. Brain Behav Immun. 2015 Oct 24.

  20. Postnatal TLR2 activation impairs learning and memory in adulthood. 
    Madar R, Rotter A, Ben-Asher HW, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP, Okun EBrain Behav Immun. 2015 May 26.

  21. DAMPs as mediators of sterile inflammation in aging-related pathologies. 
    Feldman N, Rotter A, Okun E. Ageing Res Rev. 2015 Jan 29.

  22. No ECSIT-stential evidence for a link with Alzheimer's disease yet.
    (retrospective on DOI 10.1002/bies.201100193). 
    Illouz T and Okun E.  Bioessays. 2014 Nov 4.

  23. Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans.
    Barak B, Feldman N and Okun E.  J Gerontol A Biol Sci Med Sci. 2014 Sep 16.

  24.  Toll-like receptors as developmental tools that regulate neurogenesis during development: an update. 
    Barak B, Feldman N and Okun E. Front Neurosci. 2014 Aug 28.

  25. Pancreatic polypeptide inhibits somatostatin secretion.
    Kim W, Fiori JL, Shin YK, Okun E, Kim JS, Rapp PR and Egan JM. FEBS Lett. 2014 Aug 25.

  26. A heavy toll on the outcome of ischemic brain stroke.
    Okun E. Experimental Neurology, April 2014.

  27. Tellurium Compound AS101 Ameliorates Experimental Autoimmune Encephalomyelitis by VLA-4 Inhibition and Suppression of Monocyte and T Cell Infiltration into the CNS.
    Lee JH, Halperin-Sheinfeld M, Baatar D, Mughal MR, Tae HJ, Kim JW, Carter A, Lustig A, Snir O, Lavie G, Okun E, Mattson MP, Sredni B, Taub DD. Neuromolecular Med. 2013 Nov 23.

  28. Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.
    Okun E, Griffioen KJ, Sarah R, Wan R, Cong WN, De Cabo R, Montalvo AM, Levette A, Maudsley S, Martin B, Arumugam TV, Mattson MP.  Brain Behav Immun. 2013 Oct 18.

  29. Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models.
    Barak B ,Shvarts-Serebro I,  Modai S , Gilam A, Okun E, Michaelson DM , Mattson MP, Shomron N, Ashery U. Transl Psychiatry. 2013 Sep 10.

  30. Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory.
    Barak B, Okun E, Ben-Simon Y, Lavi A, Shapira R, Madar R, Wang Y, Norman E, Sheinin A, Pita MA, Yizhar O, Mughal MR, Stuenkel E, van Praag H, Mattson MP, Ashery U. Neuromolecular Med. 2013 Mar 22.

  31. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.
    Kashiwaya Y, Bergman C, Lee JH, Wan R, Todd King M, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL. Neurobiol Aging. 2012 Dec 29.

  32. Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.
    Chigurupati S, Mughal MR, Okun E, Das S, Kumar A, McCaffery M, Seal S, Mattson MP. Biomaterials. 2012 Dec 21.

  33. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines.
    Cheng A, Wan R, Yang JL, Ka,imura N, Son TG, Ouyang X, Luo Y, Okun E, Mattson MP.  Nature communications 2012 Dec 4.

  34. Evidence for a Developmental Role for TLR4 in Learning and Memory.
    Okun E, Barak B, Saada-Madar R, Rothman SM, Griffioen KJ, Roberts N, Castro K, Mughal MR, Pita MA, Stranahan AM, Arumugam TV, Mattson MP. PLoS ONE. 2012 Oct 11. 

  35. Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.
    Griffioen KJ, Rothman SM, Ladenheim B, Wan R, Vranis N, Hutchison E, Okun E, Cadet JL, Mattson MP. Neurobiol Aging. 2012 Aug 9.

  36. The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.
    Halperin-Sheinfeld M, Gertler A, Okun E, Sredni B and Cohen HY. Aging (Albany NY). 2012 Jun.

  37. DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.
    Olkhanud PB, Mughal M, Ayukawa K, Malchinkhuu E, Bodogai M, Feldman N, Rothman S, Lee JH, Chigurupati S, Okun E, Nagashima K, Mattson MP, Biragyn A. Vaccine. 2012 Jan 14.

  38. Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease.
    Griffioen KJ, Wan R, Brown TR, Okun E, Camandola S, Mughal MR, Phillips TM, Mattson MP. Neurobiol Aging 2011 Dec 31.

  39. Toll-Like Receptor signaling in neural plasticity and disease.
    Okun E, Griffioen KJ, Mattson MP. Trends in Neuroscience. 16 Mar 2011.

  40. Evidence for Altered Numb Isoform Levels in Alzheimer's Disease Patients and a Triple Transgenic Mouse Model.
    Chigurupati S, Madan M, Okun E, Wei Z, Pattisapu JV, Mughal MR, Mattson MP, Chan SL. J Alzheimers Dis. 2011 Jan 21.

  41. Tomosyn expression pattern in the mouse hippocampus suggests both presynaptic and postsynaptic functions.
    Barak B, Williams A, Bielopolski N, Gottfried I, Okun E, Brown M, Matti U, Rettig J, Steunkel E and Ashery U. Front Neuroanat. 2010 Dec 20;4:149.

  42. Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.
    Mughal MR, Baharani A, Chigurupati S, Son TG, Chen E, Yang P, Okun E, Arumugam T, Chan SL, Mattson MP. Hum Mol Genet. 2011 Feb 15;20(4):659-69.

  43. GLP-1 receptor stimulation depresses spectral measures of heart rate variability and inhibits eurotransmission to cardiac vagal neurons.
    Griffioen K, Wan R, Okun E, Wang X, Lovett-Barr MR, Mughal RM, Greig N, Mendelowitz D, Mattson MP. Cardiovasc Res. 2011 Jan 1;89(1):72-8.

  44. Toll-like Receptor 3 Impairs Memory Retention and Constrains Adult Hippocampal Neurogenesis.
    Okun E, Griffioen K, Barak B, Roberts JN, Castro K, Pitta M, Cheng A, Mughal RM, Wan R, Ashery U and Mattson MP. Proc Natl Acad Sci. 2010 Aug 31;107 (35):15625-30.
    * ‘Highlight’ published in Nature Reviews Neuroscience by Kingwell K. working memory takes its toll. Oct 2010. In press.
    ** Selected by the faculty of 1000 medicine as among the top 2% of articles published in biology and medicine.        Available at:
    *** ‘News story’: Madolyn Bowman Rogers. A Toll on Memory: New Role for Immune-Related Receptor in Brain. Alzheimer Research Forum. August 22, 2010. Available at:
  45. Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.
    Thundyil J, Tang SC, Okun E, Shah K, Karamyan VT, Li YI, Woodruff TM, Taylor SM, Jo DG, Mattson MP, Arumugam TV. Exp Transl Stroke Med. 2010 Aug 11;2(1):15.

  46. TLR2 activation inhibits embryonic Neuronal progenitor cell proliferation.
    Okun E, Kathleen J. Griffioen, Tae Gen Son, Jong-Hwan Lee, Nicholas J. Roberts, Mohamed R. Mughal, Emmette Hutchison, Aiwu Cheng, Thiruma V. Arumugam, Justin D. Lathia, Henriette van Praag and Mark P. Mattson. J Neurochem. 2010 Jul;114(2):462-74.

  47. Involvement of Fc Receptors in Disorders of the Central Nervous System.
    Okun E, Mattson MP, Arumugam TV. Neuromolecular Med. 2009 Oct 21.

  48. The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair.
    Hutchison ER, Okun E, Mattson MP. Neuromolecular Med. 2009;11(3):153-61.

  49. Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides.
    Okun E, Lathia JD, Mattson MP. Cell Adh Migr. 2009 Jul 8;3(3).

  50. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia Cells.
    Hayun R, Okun E, Berrebi A, Shvidel L, Bassous L, Sredni B, Nir U. Leuk Lymphoma. 2009 Apr;50(4):625-32.

  51. Phosphothioated oligodeoxynucleotides induce nonspecific effects on neuronal cell adhesion in a growth substrate-dependent manner. 
    Okun E, Mattson MP.  J Neurosci Res. 2009 Jun;87(8):1947-52.

  52. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.
    Lathia JD *, Okun E *, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP. J Neuroscience. 2008 Dec 17;28(51):13978-84; * Equal contribution as first co-author.

  53. Toll-Like Receptors in Ischemia-Reperfusion Injury.
    Arumugam TV *, Okun E *, Sung-Chun Tang, John Thundyil, Stephen M. Taylor, Trent M. Woodruff.   Shock. 2009 Jul;32(1):4-16; * Equal contribution as first co-author.

  54. Toll-Like Receptors in Neurodegeneration.
    Okun E, Griffioen K, Lathia JD, Tang SC, Mattson MP and Arumugam TV. Brain Res Rev. 2009 Mar;59(2):278-92.

  55. The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice.
    Okun E, Arumugam TV, Tang SC, Gleichmann M, Albeck M, Sredni B, Mattson MP.  J.  Neurochem. 2007 Aug;102(4):1232-41.

  56. The organotellurium compound ammonium trichloro (dioxoethylene-o,o') tellurate reacts with homocysteine to form homocystine and decreases homocysteine levels in hyperhomocysteinemic mice.
    Okun E, Dikshtein Y, Carmely A, Saida H, Frei G, Sela BA, Varshavsky L, Ofir A, Levy E, Albeck M, Sredni B. FEBS J. 2007 Jun;274(12):3159-70. Epub 2007 May 22.

  57. Novel involvement of the immunomodulator AS101 in IL-10 signaling, via the tyrosine kinase Fer.
    Hayun R, Shpungin S, Malovani H, Albeck M, Okun E, Nir U, Sredni B.  Ann N Y Acad Sci. 2007 Jan;1095:240-50.

  58. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.
    Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP.  Nat Med. 2006 Jun;12(6):621-3. Epub 2006 May 7.

  59. Experimental handling stress as infection-facilitating factor for the goldfish ulcerative disease.
    Dror M, Sinyakov MS, Okun E, Dym M, Sredni B, Avtalion RR.  Vet Immunol Immunopathol. 2006 Feb 15;109(3-4):279-87. Epub 2005 Sep 19.

  60. Upregulation of carp GDNF mRNA by the immunomodulator AS101.
    Okun E, Saida H, Albeck M, Sredni B, Avtalion RR.  Dev Comp Immunol. 2006;30(5):441-6. Epub 2005 Aug 19.

  61. Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study.
    Malkesman O, Asaf T, Shbiro L, Goldstein A, Maayan A, Weizman A, Kinor N, Okun E, Sredni B, Yadid G, and Weller A. Adv Pharmacol Sci. 2009;2009:405107.

  62. Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model.
    Hayun M, Okun E, Hayun R, Gafter U, Albeck M, Longo DL, Sredni B. Leukemia. 2007 May 17.

Articles and Chapters in Books
1.  Neuronal Vulnerability to Oxidative Damage in Aging.
 Okun E, Mattson MP. Oxidative Neural Injury. 2009 83-95.

2. Basis of Ionic dysregulation in Cerebral Ischemia. New strategies in stroke intervention.
Arumugam TV, Okun E, and Mattson MP. Ionic transporters, Pumps and New Channels. 2009 1-12.

3. Roles of Inflammation and Innate Immunity in the Aging Brain. Okun E, Chen R and Mark P. Mattson. In preparation for: Inflammation, Life Style and Chronic Diseases: The Silent Link. (In Press).
1. Method of treating fish and crustaceans with a tellurium based immunomodulator (2008).
Sredni B, Albeck M, Avtalion RR, Okun E.
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