​

Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer's disease. Ben-Ami L, Ravona-Springer R, Tsarfaty G,  Raizman R, Shumacher A, Sharvit-Ginon I, Greenbaum L, B Bendlin B, Okun E,  Heymann A, Schnaider Beeri M,  Livny A.  Front Aging Neurosci​ 2023 Feb 1.

Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers.

Habashi M, Vutla S, Tripathi K, Senapati S,  Chauhan PS, Haviv-Chesner A, Richman M, Mohand SA, Dumulon-Perreault V, Mulamreddy R, Okun E, Chill JH, Guérin B, Lubell WD, Rahimipour S. PNAS. 2022 Oct 20.

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Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice.
Samuel I, Ben Haroush, Schyr R, Arad Y, Attali T, Azulai S, Bergel M, Halfon A, Hefetz L, Hirsch T, Israeli H, Lax N, Nitzan K, 
Sender D, Sweetat S,  Okun E, Rosenmann H and Ben-Zvi D. Front Neurosci​ .2022 Aug 11.
 

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain.

Yong-Quan Ng G, Sheng D, Bae HG, Kang SW, Yang-Wei Fann D, Park J, Kim J, Alli-Shaik A, Lee J, Kim E,  Park S, Han JW, Karamyan V, Okun E, Dheen T,  Hande MP, Vemuganti R, Mallilankaraman K, Lim HKL, Kennedy BK,  Drummond GR, Sobey CG, Gunaratne J, Mattson MP, Sik-Yin Foo R, Dong-Gyu Jo and Thiruma V. Arumugam. GeroScience. 2022 Aug.

HCAR1‑Mediated l‑Lactate Signaling Suppresses Microglial Phagocytosis. 
Nicola R, Madar R and  Okun E. NeuroMolecular Medicine, April 2022.

COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated.
Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A,  
Chicoine BA,  Ghosh S, Lakhanpaul M,  Levin J, Lunsky Y, Manso C, Okun E, Real de Asua D, Rebillat AS,  Rohrer TR,  Sgandurra G,  Valentini D, Sherman SL and Strydom A.  Vaccines (Basel)​ 2022 Mar 29.
 

Physiology and pharmacology of amyloid precursor protein. 

Cho Y, Bae HG, Okun E, Arumugam TV, Jo DG. Pharmacol Ther. 2022 Feb 1

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Induction of an effective anti-Amyloid-beta humoral response in aged mice. 

Illouz T, Madar R , Hirsh T , Biragyn A  and Okun E. Vaccine, July 2021.
 

Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.
Illouz T, Biragyn A, Florencia Iulita M, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis S.E, Yu E, Herault Y, Potier M.C, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A and  Okun E. on behalf of T21RS COVID-19 Initiative. Front. Immunol., 25 June 2021.
 

Therapeutic B-cell depletion reverses progression of Alzheimer's disease.

Kim K, Wang X, Ragonnaud E, Bodogai M,  Illouz T, DeLuca M,  McDevitt R.A,  Gusev F, Okun E, Rogaev E and Biragyn A. Nat Commun. 2021 Apr 12.
 

Adult Hippocampal Neurogenesis: One Lactate to Rule Them All.

Nicola R and Okun E. NeuroMolecular Medicine. 19 April 2021.
 

Specific Susceptibility to COVID-19 in Adults with Down Syndrome.  

Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I,  Iulita F, Flores-Aguilar L, Dierssen Sotos M, De Toma H, Lifshitz H, Antonarakis S.E, Yu E, Herault Y, Potier M.C, Botté A, Roper R, Sredni B, Sarid R, London J,  Mobley W, Strydom A and Okun E.  NeuroMolecular Medicine. 4 March 2021.
 

High‑Intensity Functional Training: Molecular Mechanisms and Benefits​. 

B. Zeev T and Okun E. NeuroMolecular Medicine. 01 January 2021.
 

Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis.

Illouz T, Nicola R, Ben-Shuhan L, Madar R, Biragyn R and Okun E. Communications Biology. 12 March 2021. 
 

Mild physical activity does not improve spatial learning in a virtual environment.
Okun E, B. Zeev T, Weiss I, Ashri S, Heled Y, Ketko I and Yanovich R. Front. Behav. Neurosci. 17 november 2020.
 

The effects of High-Intensity Functional Training (HIFT) on spatial learning, visual pattern separation and attention span in adolescents. 
Okun E, Ben-Zeev T, Hirsh T, Weiss I and Gornstein M. Front. Behav. Neurosci. 21 August 2020.
 

Food and Age: It Takes Two to Degenerate​. 
Nicola R and Okun E. Front. Aging Neurosci., 26 June 2020.
 

A modified Barnes maze for an accurate assessment of spatial learning in mice. 
Illouz T, Madar R and Okun E. J Neurosci Methods. Jan 2020.
 

L-Lactate Promotes Adult Hippocampal Neurogenesis. 
Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Feldman N, Roichman A, Illouz T, Varvak A, Nicola R, Madar R and Okun E. Front. Neurosci., 24 May 2019. 
 

Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model.
Illouz T., Madar R., Biragyn A. and Okun E. Brain, Behavior, and Immunity, 2018 Oct 23.
 

Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair.
De Lorenzo G, Ferrari S, Cervone F and Okun E. Trends Immunol. 2018 Oct 4.
 

The Toll Pathway in the Central Nervous System of Flies and Mammals.
Shmueli A, Shalit T, Okun E and Shohat-Ophir G. Neuromolecular Med. 2018 Oct 1.
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Dopamine receptors in the rat entopeduncular nucleus.
Lavian H, Loewenstern Y, Madar R, Almog M, Bar-Gad I, Okun E and Korngreen A. Brain Struct Funct. 2018 Mar 22.
 

Deficiency of Toll-like receptors 2, 3 or 4 extendslife expectancy inHuntington’s disease mice​

Griffioen K, Mattson MP, Okun E. Heliyon. 2018 Jan 18.

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A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42. 

Illouz T , Madar R, Griffioen K and Okun E. J Neurosci Methods. 2017 Nov 1.

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Dopaminergic modulation of synaptic integration and firing patterns in the rat entopenduncular nucleus. 
​Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A. J Neurosci. 2017 Jun 26.
 

Sirt6 alters adult hippocampal neurogenesis.
Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY. PLoS One. 2017 Jun 23.
 

The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study.
Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun E, Yadid G and Popovtzer R. Nanomedicine. 2017 June 16.
 

Toll-like receptor 3 deficiency decreases epileptogenesis in pilocarpine model of SE-induced epilepsy in mice.
Gross A, Benninger F ,Madar R, Illouz T, Griffioen K, Steiner I, Offen D and Okun E. Epilepsia. 2017 Feb 6.
 

Unbiased classification of spatial strategies in the Barnes maze. 
Illouz T , Madar R, Clague C , Griffioen K, Louzoun Y and Okun E. Bioinformatics. 2016 July 4.
 

Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm.
Illouz T, Madar R, Louzon Y, Griffioen KJ, Okun E. Brain Behav Immun. 2015 Oct 24.
 

Postnatal TLR2 activation impairs learning and memory in adulthood. 
Madar R, Rotter A, Ben-Asher HW, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP, Okun E. Brain Behav Immun. 2015 May 26.
 

DAMPs as mediators of sterile inflammation in aging-related pathologies. 
Feldman N, Rotter A, Okun E. Ageing Res Rev. 2015 Jan 29.
 

No ECSIT-stential evidence for a link with Alzheimer's disease yet.
Illouz T and Okun E.  Bioessays. 2014 Nov 4.
 

Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans.
Barak B, Feldman N and Okun E.  J Gerontol A Biol Sci Med Sci. 2014 Sep 16.
 

 Toll-like receptors as developmental tools that regulate neurogenesis during development: an update. 
Barak B, Feldman N and Okun E. Front Neurosci. 2014 Aug 28.